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M V Relling Selected Research

Asparaginase (Elspar)

1/2017Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia.
1/2017Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.
6/2014Successful challenges using native E. coli asparaginase after hypersensitivity reactions to PEGylated E. coli asparaginase.
11/2012Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia.
1/2011A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity.
8/2010Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
12/2009Comparison of native E. coli and PEG asparaginase pharmacokinetics and pharmacodynamics in pediatric acute lymphoblastic leukemia.
6/2004Asparaginase pharmacodynamics differ by formulation among children with newly diagnosed acute lymphoblastic leukemia.
8/2003Evaluation of immunologic crossreaction of antiasparaginase antibodies in acute lymphoblastic leukemia (ALL) and lymphoma patients.
5/2000ELISA to evaluate plasma anti-asparaginase IgG concentrations in patients with acute lymphoblastic leukemia.
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M V Relling Research Topics

Disease

29Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2017 - 02/2000
8Leukemia
01/2017 - 04/2000
8Hypersensitivity (Allergy)
01/2017 - 04/2000
7Neoplasms (Cancer)
08/2013 - 02/2000
4Residual Neoplasm
01/2017 - 01/2004
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2008 - 11/2000
3Myeloid Leukemia (Leukemia, Myelocytic)
02/2010 - 02/2000
2Asthma (Bronchial Asthma)
01/2017 - 03/2007
2Infections
01/2017 - 07/2000
2Febrile Neutropenia
01/2017 - 02/2009
2Lymphoma (Lymphomas)
08/2003 - 02/2001
1Otitis
01/2017
1Fatty Liver
01/2017
1Second Primary Neoplasms (Neoplasms, Second)
12/2014
1Glucosephosphate Dehydrogenase Deficiency
08/2014
1Hemolytic Anemia
08/2014
1Methemoglobinemia
08/2014
1Ototoxicity
08/2013
1Functional Hearing Loss
08/2013
1Hearing Loss (Hearing Impairment)
08/2013
1Brain Neoplasms (Brain Tumor)
02/2010
1Drug-Related Side Effects and Adverse Reactions
05/2007
1Cardiovascular Diseases (Cardiovascular Disease)
03/2007
1Thrombosis (Thrombus)
06/2004
1Anaphylaxis (Anaphylactic Shock)
08/2003
1Non-Hodgkin Lymphoma (Lymphosarcoma)
06/2001
1Necrosis
06/2001
1Neutropenia
06/2001
1Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia)
06/2001
1Thiopurine S methyltranferase deficiency
04/2001
1Hyperuricemia
02/2001
1Body Weight (Weight, Body)
04/2000

Drug/Important Bio-Agent (IBA)

11Asparaginase (Elspar)FDA Link
01/2017 - 04/2000
5Pharmaceutical PreparationsIBA
06/2014 - 07/2000
5AntibodiesIBA
11/2012 - 04/2000
5Etoposide (VP 16)FDA LinkGeneric
02/2010 - 06/2001
4Methotrexate (Mexate)FDA LinkGeneric
01/2017 - 02/2000
4pegaspargase (Oncaspar)FDA Link
06/2014 - 08/2003
4Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric
02/2009 - 04/2000
3thiopurine methyltransferase (thiopurine S-methyltransferase)IBA
01/2017 - 04/2000
3DNA (Deoxyribonucleic Acid)IBA
12/2010 - 10/2007
2Prednisone (Sone)FDA LinkGeneric
01/2017 - 06/2001
2EnzymesIBA
08/2014 - 03/2007
2rasburicase (Elitek)FDA Link
08/2014 - 02/2001
22-mercaptopurineIBA
02/2009 - 11/2000
2Type II DNA Topoisomerases (Topoisomerase II)IBA
12/2008 - 11/2000
2Podophyllotoxin (Condylox)FDA LinkGeneric
12/2008 - 02/2000
2Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
06/2004 - 08/2003
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2017
1Transaminases (Aminotransferases)IBA
01/2017
1Dihydrotachysterol (AT 10)IBA
12/2014
1Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA
08/2014
1Cholecalciferol (Vitamin D3)FDA Link
05/2014
1CalciumIBA
05/2014
1Cisplatin (Platino)FDA LinkGeneric
08/2013
1Messenger RNA (mRNA)IBA
12/2010
1Adrenergic Receptors (Adrenergic Receptor)IBA
12/2010
1PyrophosphatasesIBA
02/2009
1Inosine Triphosphate (ITP)IBA
02/2009
1Biological ProductsIBA
10/2007
1Proteins (Proteins, Gene)FDA Link
03/2007
1NicotineFDA Link
03/2007
1Membrane Transport Proteins (Biological Pump)IBA
03/2007
1AsparagineIBA
06/2004
1Antigen Receptors (Antigen Receptor)IBA
01/2004
1NucleotidesIBA
02/2002
1Thioguanine (Tioguanine)FDA Link
02/2002
1Therapeutic UsesIBA
11/2001
1Topoisomerase II InhibitorsIBA
08/2001
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
06/2001
1Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric
06/2001
1Cytochrome P-450 CYP3AIBA
06/2001
1Atovaquone (Mepron)FDA Link
06/2001
1Azathioprine (Imuran)FDA LinkGeneric
04/2001
1CreatinineIBA
02/2001
1AllantoinIBA
02/2001
1Phosphorus (Red Phosphorus)IBA
02/2001
1Uric Acid (Urate)IBA
02/2001
1Urate Oxidase (Uricase)IBA
02/2001
1Anticonvulsants (Antiepileptic Drugs)IBA
07/2000
1Immunoglobulin G (IgG)IBA
05/2000
1Antipyrine (Phenazone)FDA Link
04/2000
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
04/2000
1Glutathione Transferase (Glutathione S-Transferase)IBA
02/2000

Therapy/Procedure

25Therapeutics
01/2017 - 02/2000
5Remission Induction
01/2017 - 06/2001
4Drug Therapy (Chemotherapy)
01/2017 - 07/2000
2Cranial Irradiation
12/2014 - 02/2010
2Aftercare (After-Treatment)
12/2010 - 02/2001
1Craniospinal Irradiation
08/2013
1Hematopoietic Stem Cell Transplantation
02/2010
1Combination Drug Therapy (Combination Chemotherapy)
02/2009
1Maintenance Chemotherapy
06/2001